Title : A method for the determination of UDP-glucuronosyltransferase activity toward arylcarboxylic acids.

Pub. Date : 1993 Aug 1

PMID : 8214591






1 Functional Relationships(s)
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1 The technique was validated for each of the seven substrates tested by reversed-phase HPLC, and was then applied successfully to the determination of optimal conditions for the activation of the carboxylic acid-UGT, and the estimation of kinetic constants for the glucuronidation of clofibric acid, 2-naphthylacetic acid, naproxen, and 4,4,4-triphenylbutanoic acid in rat liver microsomes. Clofibric Acid UDP glycosyltransferase 2 family, polypeptide B Rattus norvegicus