Pub. Date : 1994 May 15
PMID : 8198542
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | SDS/PAGE revealed that oleic acid enhances urokinase activity but simultaneously increases the autolytic cleavage of the newly formed low-molecular-mass subunit of plasmin. | Oleic Acid | plasminogen | Homo sapiens |
| 2 | Oleic acid-induced cleavage of this subunit containing the catalytic site of plasmin was suppressed by the plasmin substrate H-D-valyl-L-leucyl-L-lysine-p-nitroanilide (S-2251) and was prevented by alpha 2-antiplasmin. | Oleic Acid | plasminogen | Homo sapiens |
| 3 | Oleic acid-induced cleavage of this subunit containing the catalytic site of plasmin was suppressed by the plasmin substrate H-D-valyl-L-leucyl-L-lysine-p-nitroanilide (S-2251) and was prevented by alpha 2-antiplasmin. | Oleic Acid | plasminogen | Homo sapiens |
| 4 | A concentration-dependent inhibition of the activity of purified plasmin on 125I-labelled fibrin clot was also observed; 93% and 50% inhibition was noted with 150 microM and 32 microM oleic acid respectively. | Oleic Acid | plasminogen | Homo sapiens |
| 5 | Oleic acid at 200 microM also effectively displaced plasmin prebound to a polylysine-Sepharose column. | Oleic Acid | plasminogen | Homo sapiens |
| 6 | Oleic acid at a concentration that produced only a minimal inhibition of plasmin activity induced a marked inhibition by palmitic acid, while palmitic acid alone is ineffective. | Oleic Acid | plasminogen | Homo sapiens |
| 7 | The findings suggest that oleic acid stimulates plasminogen activation and modulates the fibrinolytic and autolytic activities of plasmin. | Oleic Acid | plasminogen | Homo sapiens |