Title : Basis of selectivity of antibacterial diaminopyrimidines.

Pub. Date : 1993 Dec

PMID : 8195830






1 Functional Relationships(s)
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1 Thus, the TMP binding affinity of E. coli DHFR is increased by NADPH in the ternary complex, and this increased affinity (cooperativity) varies with methoxy group substitution. NADP Dihydrofolate reductase Escherichia coli