Title : Interleukin-1 beta maturation and release in response to ATP and nigericin. Evidence that potassium depletion mediated by these agents is a necessary and common feature of their activity.

Pub. Date : 1994 May 27

PMID : 8195155






5 Functional Relationships(s)
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Protein Name
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1 Interleukin-1 beta maturation and release in response to ATP and nigericin. Nigericin interleukin 1 beta Mus musculus
2 The potassium-proton ionophore nigericin and ATP are known to promote the maturation and release of IL-1 beta from LPS-stimulated cells. Nigericin interleukin 1 beta Mus musculus
3 Like nigericin, the ionophores A204 and lasalocid induced the release and maturation of IL-1 beta. Nigericin interleukin 1 beta Mus musculus
4 ADP was less active than ATP at initiating the post-translational maturation and release of IL-1 beta and AMP, GTP, and UTP were totally inactive, ATP, nigericin, A204, and lasalocid promoted a rapid and complete loss of the potassium analog 86Rb+ from cells that were preloaded with this cation; valinomycin-treated cells released only a portion of the radiolabeled cation. Nigericin interleukin 1 beta Mus musculus
5 These data suggest that ATP and nigericin induce a net decrease in intracellular levels of K+ which is necessary for activation of the post-translational maturation of IL-1 beta. Nigericin interleukin 1 beta Mus musculus