Title : Proteolytic inactivation of alpha-1-antitrypsin by human neutrophils: involvement of multiple and interlinked cell responses to phagocytosable targets.

Pub. Date : 1994 Jan

PMID : 8187807






3 Functional Relationships(s)
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1 During OPZ-triggering, PMN used approximately 80% of the generated hydrogen peroxide (H2O2) to produce HOCl by means of the MPO pathway, while the remainder was catabolized by PMN themselves. Hypochlorous Acid myeloperoxidase Homo sapiens
2 The selective deletion of single components of the HOCl-generating MPO pathway resulted in the generation of PMN supernatants free of active metalloenzymes but rich of the corresponding zymogens. Hypochlorous Acid myeloperoxidase Homo sapiens
3 On concluding, PMN undergoing phagocytosis release MPO in amount sufficient to handle the extracellular pool of the generated H2O2 entirely, leading to the generation of equimolar amounts of HOCl. Hypochlorous Acid myeloperoxidase Homo sapiens