Title : Protein kinase C is not involved in the cytotoxic action of 1-octadecyl-2-O-methyl-sn-glycerol-3-phosphocholine in HL-60 and K562 cells.

Pub. Date : 1994 Apr 29

PMID : 8185658






3 Functional Relationships(s)
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1 However, membrane-bound PK-C activity in the sensitive HL-60 cells was approximately 3-fold increased in the presence of ET-18-OCH3, whereas in differentiated HL-60 cells and K562 cells PK-C was not influenced by ET-18-OCH3. edelfosine proline rich transmembrane protein 2 Homo sapiens
2 Moreover, cells depleted of PK-C activity showed similar sensitivity or resistance to ET-18-OCH3 as cells expressing PK-C activity. edelfosine proline rich transmembrane protein 2 Homo sapiens
3 These results suggest that a role of PK-C in the cytotoxic action of ET-18-OCH3 is very unlikely. edelfosine proline rich transmembrane protein 2 Homo sapiens