Pub. Date : 1994 Apr
PMID : 8184986
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In the urethra, NPY (0.02-0.5 microM) decreased the release of [3H]NE in a dose-dependent manner (10-53%). | Tritium | neuropeptide Y | Rattus norvegicus |
| 2 | In the bladder base the inhibitory effect of NPY on [3H]NE release was not dose dependent. | Tritium | neuropeptide Y | Rattus norvegicus |
| 3 | These observations suggest that 0.5 microM NPY elicits two opposing actions: a direct inhibitory action on adrenergic terminals and an indirect disinhibitory action to eliminate heterosynaptic cholinergic inhibition of [3H]NE release. | Tritium | neuropeptide Y | Rattus norvegicus |
| 4 | In both tissues the action of NPY on [3H]NE release was not significantly modified by the alpha-adrenergic blocking agent yohimbine (1 microM). | Tritium | neuropeptide Y | Rattus norvegicus |
| 5 | [3H]ACh release in the bladder body was not altered by 0.1 microM NPY but was suppressed (39%) by 1 microM NPY. | Tritium | neuropeptide Y | Rattus norvegicus |
| 6 | The effect of NPY (1 microM) on [3H]ACh release was dependent on the frequency of stimulation. | Tritium | neuropeptide Y | Rattus norvegicus |