Title : Stimulatory and inhibitory action of nitric oxide donor agents vs. nitrovasodilators on reactive oxygen production by isolated polymorphonuclear leukocytes.

Pub. Date : 1994 May

PMID : 8182511






2 Functional Relationships(s)
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1 Unlike the nitrovasodilators, nitroglycerin and nicorandil, the nitric oxide donor agents, 3-morpholinosydnonimine (SIN-1) and sodium nitroprusside, both produced enhanced stimulation of LDCL following zymosan at low concentrations of the agonist and inhibition at high concentrations of the agonist. Zymosan MAPK associated protein 1 Homo sapiens
2 In zymosan-stimulated cells, the enhanced LDCL induced by SIN-1 was prevented with superoxide dismutase, catalase (but not mannitol) and reversed with L-nitroarginine methyl ester. Zymosan MAPK associated protein 1 Homo sapiens