Title : Structural constraints of inhibitors for binding at two active sites on somatic angiotensin converting enzyme.

Pub. Date : 1994 Feb 15

PMID : 8174603






1 Functional Relationships(s)
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1 Reduction in affinity at the amino binding site of somatic angiotensin converting enzyme was related to an increased side chain size (lung KDA (pM): Ro 31-8472 175 +/- 38, lisinopril 2205 +/- 1832, and 351A 2271 +/- 489), or hydrophobicity of the competing unlabelled angiotensin converting enzyme inhibitor (lung KDA (pM): quinaprilat 1267 +/- 629 and perindoprilat 824 +/- 6). Lisinopril angiotensin I converting enzyme Rattus norvegicus