Title : Synthesis of myristoyl CoA analogues and myristoyl peptides as inhibitors of myristoyl CoA:protein N-myristoyltransferase.

Pub. Date : 1994 Feb

PMID : 8169796






1 Functional Relationships(s)
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1 Biological evaluation of these compounds in an in vitro NMT enzyme assay revealed that the nonhydrolyzable acyl CoA analogue 1 was the most potent inhibitor [inhibitor dissociation constant (Ki) = 24 nM]. Acyl Coenzyme A N-myristoyltransferase 1 Homo sapiens