Title : Modulation of A beta adhesiveness and secretase site cleavage by zinc.

Pub. Date : 1994 Apr 22

PMID : 8163520






3 Functional Relationships(s)
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1 We studied the binding of Zn2+ to a synthetic peptide representing residues 1-40 (A beta 1-40), as well as other domains of A beta. Zinc amyloid beta precursor protein Homo sapiens
2 Zinc binding also increased A beta resistance to tryptic cleavage at the secretase site, indicating that a small (<3 microM) increase in brain Zn2+ concentration could significantly alter A beta metabolism. Zinc amyloid beta precursor protein Homo sapiens
3 Zinc binding also increased A beta resistance to tryptic cleavage at the secretase site, indicating that a small (<3 microM) increase in brain Zn2+ concentration could significantly alter A beta metabolism. Zinc amyloid beta precursor protein Homo sapiens