Title : Human insulin-like growth factor I receptor internalization. Role of the juxtamembrane domain.

Pub. Date : 1994 Apr 22

PMID : 8163493






4 Functional Relationships(s)
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1 The rate of 125I-labeled IGF-1 internalization by transfectants overexpressing the wild type IGF-1 receptor was rapid but decreased markedly in the presence of increasing unlabeled IGF-1 (ED50 = 44,000 receptors/cell). Iodine-125 insulin like growth factor 1 Homo sapiens
2 The rate of 125I-labeled IGF-1 internalization by transfectants overexpressing the wild type IGF-1 receptor was rapid but decreased markedly in the presence of increasing unlabeled IGF-1 (ED50 = 44,000 receptors/cell). Iodine-125 insulin like growth factor 1 Homo sapiens
3 The rate of 125I-labeled IGF-1 internalization by transfectants overexpressing the wild type IGF-1 receptor was rapid but decreased markedly in the presence of increasing unlabeled IGF-1 (ED50 = 44,000 receptors/cell). Iodine-125 insulin like growth factor 1 Homo sapiens
4 In contrast, 125I-labeled IGF-1 endocytosis by the mutant kinase-deficient 952STOP cells was slow and not further retarded by unlabeled IGF-1. Iodine-125 insulin like growth factor 1 Homo sapiens