Title : Molecular analysis of hprt gene mutations in skin fibroblasts of rats exposed in vivo to N-methyl-N-nitrosourea or N-ethyl-N-nitrosourea.

Pub. Date : 1994 May 1

PMID : 8162597






1 Functional Relationships(s)
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1 These results indicate that MNU and ENU induce different mutational spectra in vivo and that DNA repair systems remove O6-methylguanine, O2, and/or O4-ethylthymidine much faster from the transcribed strand than the nontranscribed strand of the hprt gene in these rat fibroblasts. O-(6)-methylguanine hypoxanthine phosphoribosyltransferase 1 Rattus norvegicus