Pub. Date : 1994 May 1
PMID : 8162591
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Quercetin mediates the down-regulation of mutant p53 in the human breast cancer cell line MDA-MB468. | Quercetin | tumor protein p53 | Homo sapiens |
| 2 | We have correlated these effects on cell proliferation with the observation that quercetin strongly inhibited, in a time- and dose-dependent fashion, the expression of the mutated p53 protein, which is the only form present at high levels in this cell line. | Quercetin | tumor protein p53 | Homo sapiens |
| 3 | Quercetin did not affect the steady-state mRNA levels of p53, but prevented the accumulation of newly synthesized p53 protein. | Quercetin | tumor protein p53 | Homo sapiens |
| 4 | This quercetin action appeared to be somewhat specific for p53 because the drug did not alter the amount of other proteins present in MDA-MB468 cells such as P-glycoprotein and did not prevent the induction of the synthesis of epidermal growth factor receptor in response to epidermal growth factor. | Quercetin | tumor protein p53 | Homo sapiens |