Title : Induction of resistance to fluorodeoxyuridine cytotoxicity and DNA damage in human tumor cells by expression of Escherichia coli deoxyuridinetriphosphatase.

Pub. Date : 1994 May 1

PMID : 8162567






1 Functional Relationships(s)
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1 Recent studies from our laboratory suggested that, in some human colorectal tumor cell lines, sensitivity to fluorodeoxyuridine may depend upon the extent of dUTP accumulation that occurs following drug treatment and that elevation of dUTPase activity might be the basis for some instances of resistance to fluoropyrimidines. deoxyuridine triphosphate Deoxyuridine triphosphatase Drosophila melanogaster