Title : Induction of resistance to fluorodeoxyuridine cytotoxicity and DNA damage in human tumor cells by expression of Escherichia coli deoxyuridinetriphosphatase.

Pub. Date : 1994 May 1

PMID : 8162567






2 Functional Relationships(s)
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1 To test this model, we expressed Escherichia coli dUTPase in an established human tumor cell line (HT29) and measured the effect of this manipulation on response to fluorodeoxyuridine. Floxuridine Deoxyuridine triphosphatase Drosophila melanogaster
2 As predicted, HT29 derivatives containing dUTPase activity 4-5-fold higher than controls were protected from fluorodeoxyuridine-induced loss of clonogenicity and from formation of DNA double strand breaks. Floxuridine Deoxyuridine triphosphatase Drosophila melanogaster