Title : Direct detection of radical generation in rat liver nuclei on treatment with tumour-promoting hydroperoxides and related compounds.

Pub. Date : 1994 Apr 12

PMID : 8155740






1 Functional Relationships(s)
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1 Experiments with NADPH/NADH, heat denaturation of the nuclei and various inhibitors suggest that radical generation is an enzymatic process catalysed by haemoproteins, in particular cytochrome P-450, and that NADPH/cytochrome P-450 reductase is involved in the reductive cleavage of the O-O bond. NADP cytochrome p450 oxidoreductase Rattus norvegicus