Title : Differences between the sugar moieties of liver- and bone-type alkaline phosphatases: a re-evaluation.

Pub. Date : 1994 Jan

PMID : 8154849






7 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Sialic acid was added to ALP sugar moieties by alpha 2,3- or 2,6-sialyltransferase treatment of the asialo-form ALP (neuraminidase-treated ALP). Sugars ATHS Homo sapiens
2 Sialic acid was added to ALP sugar moieties by alpha 2,3- or 2,6-sialyltransferase treatment of the asialo-form ALP (neuraminidase-treated ALP). Sugars ATHS Homo sapiens
3 Sialic acid was added to ALP sugar moieties by alpha 2,3- or 2,6-sialyltransferase treatment of the asialo-form ALP (neuraminidase-treated ALP). Sugars ATHS Homo sapiens
4 However, after the O-linked sugar moiety had been released by additional treatment with O-glycanase the liver-like ALP became more heat stable at 56 degrees C, like non-treated liver ALP. Sugars ATHS Homo sapiens
5 However, after the O-linked sugar moiety had been released by additional treatment with O-glycanase the liver-like ALP became more heat stable at 56 degrees C, like non-treated liver ALP. Sugars ATHS Homo sapiens
6 After O-glycanase treatment, bone ALP molecules deprived of an O-linked sugar moiety had a molecular size and heat stability similar to liver ALP. Sugars ATHS Homo sapiens
7 The difference between liver and bone ALP molecules may be due not only to their manner of sialic acid linkage but also to the attachment of the O-linked sugar moiety. Sugars ATHS Homo sapiens