Title : Induction of IL-8 gene expression in human polymorphonuclear neutrophils by recombinant IL-2.

Pub. Date : 1994 Apr 1

PMID : 8144938






3 Functional Relationships(s)
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1 The protein synthesis inhibitor, cycloheximide, had no detectable effect on levels of IL-8 mRNA expression in PMN incubated in medium alone; however, cycloheximide could selectively modulate IL-8 mRNA transcription in PMN, depending on the cytokine used. Cycloheximide C-X-C motif chemokine ligand 8 Homo sapiens
2 The protein synthesis inhibitor, cycloheximide, had no detectable effect on levels of IL-8 mRNA expression in PMN incubated in medium alone; however, cycloheximide could selectively modulate IL-8 mRNA transcription in PMN, depending on the cytokine used. Cycloheximide C-X-C motif chemokine ligand 8 Homo sapiens
3 Cycloheximide did not affect or alter IL-8 mRNA induction in IL-2-treated PMN but abrogated it in granulocyte macrophage-CSF-treated PMN and super-induced the level of IL-8 mRNA in C. albicans-treated PMN. Cycloheximide C-X-C motif chemokine ligand 8 Homo sapiens