Title : rac p21 is involved in insulin-induced membrane ruffling and rho p21 is involved in hepatocyte growth factor- and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced membrane ruffling in KB cells.

Pub. Date : 1994 Apr

PMID : 8139548






5 Functional Relationships(s)
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1 Insulin-induced membrane ruffling was inhibited by microinjection of rho GDI, an inhibitory GDP/GTP exchange regulator for both rho p21 and rac p21 small GTP-binding proteins, but not inhibited by microinjection of botulinum exoenzyme C3, known to selectively ADP-ribosylate rho p21 and to impair its function. Guanosine Triphosphate H3 histone pseudogene 16 Homo sapiens
2 Insulin-induced membrane ruffling was inhibited by microinjection of rho GDI, an inhibitory GDP/GTP exchange regulator for both rho p21 and rac p21 small GTP-binding proteins, but not inhibited by microinjection of botulinum exoenzyme C3, known to selectively ADP-ribosylate rho p21 and to impair its function. Guanosine Triphosphate H3 histone pseudogene 16 Homo sapiens
3 Insulin-induced membrane ruffling was inhibited by microinjection of rho GDI, an inhibitory GDP/GTP exchange regulator for both rho p21 and rac p21 small GTP-binding proteins, but not inhibited by microinjection of botulinum exoenzyme C3, known to selectively ADP-ribosylate rho p21 and to impair its function. Guanosine Triphosphate H3 histone pseudogene 16 Homo sapiens
4 This rho GDI action was prevented by comicroinjection with guanosine 5"-(3-O-thio)triphosphate (GTP gamma S)-bound rac1 p21. Guanosine Triphosphate H3 histone pseudogene 16 Homo sapiens
5 Microinjection of either GTP gamma S-bound rac1 p21 or rhoA p21 alone induced membrane ruffling in the absence of the growth factors. Guanosine Triphosphate H3 histone pseudogene 16 Homo sapiens