Title : Modulation of calcium signaling and LH secretion by progesterone in pituitary gonadotrophs and clonal pituitary cells.

Pub. Date : 1994 Jan

PMID : 8136305






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1 In the present study, the effects of gonadal steroids on GnRH-induced cytoplasmic calcium ([Ca2+]i) responses in gonadotrophs were analyzed in rat pituitary cells and immortalized (alpha T3-1) murine gonadotrophs. Steroids gonadotropin releasing hormone 1 Rattus norvegicus
2 The results demonstrate that the stimulatory and inhibitory effects of progesterone on agonist-induced Ca2+ signaling result from changes in Ca2+ mobilization and entry, and contribute to the modulatory actions of the steroid on GnRH-induced LH secretion. Steroids gonadotropin releasing hormone 1 Rattus norvegicus