Pub. Date : 1994 Mar
PMID : 8129032
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We examined the effects of cyclosporine (Cy) on preproendothelin-1 (prepro Et-1) and both Et receptors, A-type (EtA) and B-type (EtB), in rat glomerular mesangial cells. | Cyclosporine | endothelin 1 | Rattus norvegicus |
| 2 | Cy at 10(-5) mol/L, the concentration relevant to tissue levels in vivo, increased mRNA for prepro Et-1 after both 1 and 3 hours to 183 +/- 14% (n = 8) and 147 +/- 12% (n = 9) of levels seen in control cells. | Cyclosporine | endothelin 1 | Rattus norvegicus |
| 3 | These results indicate that Cy enhances expression of mRNA for prepro Et-1 and production of mature Et-1 by glomerular mesangial cells. | Cyclosporine | endothelin 1 | Rattus norvegicus |
| 4 | These results indicate that Cy enhances expression of mRNA for prepro Et-1 and production of mature Et-1 by glomerular mesangial cells. | Cyclosporine | endothelin 1 | Rattus norvegicus |