Pub. Date : 1994 Feb 28
PMID : 8123030
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Glyburide enhances insulin gene expression and glucose-induced insulin release in isolated rat islets. | Glyburide | insulin | Homo sapiens |
| 2 | Glyburide enhances insulin gene expression and glucose-induced insulin release in isolated rat islets. | Glyburide | insulin | Homo sapiens |
| 3 | Incubation with glyburide (500 ng/ml) significantly increased insulin release without affecting the insulin content. | Glyburide | insulin | Homo sapiens |
| 4 | The PPI mRNA level was not increased after incubation for 1 h but was increased after incubation for 20 h. Incubation with 5 ng/ml of glyburide for 1 h or 20 h had no effect on the content or release of insulin, but incubation with 5 ng/ml of glyburide for 20 h significantly increased the PPI mRNA level and enhanced insulin release induced by 11 mM glucose. | Glyburide | insulin | Homo sapiens |
| 5 | These results suggest that a high concentration of glyburide stimulates insulin release directly, while a low concentration of glyburide increases the PPI mRNA level and may thereby enhance glucose-induced insulin release. | Glyburide | insulin | Homo sapiens |
| 6 | These results suggest that a high concentration of glyburide stimulates insulin release directly, while a low concentration of glyburide increases the PPI mRNA level and may thereby enhance glucose-induced insulin release. | Glyburide | insulin | Homo sapiens |