Title : Mutant p53 potentiates protein kinase C induction of vascular endothelial growth factor expression.

Pub. Date : 1994 Mar

PMID : 8108142






4 Functional Relationships(s)
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1 Expression of the VEGF gene can be induced by tumor promoting phorbol esters, such as 12-O-tetradecanoylphorbol-13-acetate (TPA), which activate protein kinase C (PKC). Tetradecanoylphorbol Acetate vascular endothelial growth factor A Homo sapiens
2 Expression of the VEGF gene can be induced by tumor promoting phorbol esters, such as 12-O-tetradecanoylphorbol-13-acetate (TPA), which activate protein kinase C (PKC). Tetradecanoylphorbol Acetate vascular endothelial growth factor A Homo sapiens
3 Mutant p53 specifically increases TPA induction of VEGF without affecting the expression of other TPA inducible genes. Tetradecanoylphorbol Acetate vascular endothelial growth factor A Homo sapiens
4 TPA dependent VEGF expression is also enhanced by human p53 mutated at amino acid 175. Tetradecanoylphorbol Acetate vascular endothelial growth factor A Homo sapiens