Title : Comparison of the cardiovascular and neural activity of endothelin-1, -2, -3 and respective proendothelins: effects of phosphoramidon and thiorphan.

Pub. Date : 1993 Sep

PMID : 8106108






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Pressor responses induced by big-endothelin-1, -2 and -3 (3, 15 and 10 nmol kg-1, respectively) were markedly reduced (60, 80 and 100%) in the presence of phosphoramidon (10 mg kg-1, i.v.). phosphoramidon endothelin 1 Rattus norvegicus
2 Phosphoramidon, but not thiorphan, concentration-dependently(10 and 100 microM) reduced big-endothelin-1 (58 and 86% respectively) and big-endothelin-2 (21 and 56%)-mediated responses. phosphoramidon endothelin 1 Rattus norvegicus