Title : Interactions between the effects of opioid, serotonin and alpha-2-adrenergic receptor agonists on growth hormone release in the male rat. Intrahypothalamic administration.

Pub. Date : 1993 May

PMID : 8105398






3 Functional Relationships(s)
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1 MBH injection of the alpha 2 antagonist idazoxan 10 nmol prevented the GH rise due to clonidine, but did not inhibit release due to DAGO. Clonidine gonadotropin releasing hormone receptor Rattus norvegicus
2 Injection of DAGO and clonidine but not quipazine into the preoptic-anterior hypothalamic area (PO/AHA) increased GH release, and combination injections of DAGO and clonidine produced additive release. Clonidine gonadotropin releasing hormone receptor Rattus norvegicus
3 PO/AHA idazoxan 10 nmol prevented GH release caused by both clonidine and DAGO, suggesting that idazoxan prevents opioid-induced as well as clonidine-induced suppression of somatostatin release. Clonidine gonadotropin releasing hormone receptor Rattus norvegicus