Title : Functional consequences of phenylalanine mutations in the predicted transmembrane domain of P-glycoprotein.

Pub. Date : 1993 Sep 25

PMID : 8104183






4 Functional Relationships(s)
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1 Functional consequences of phenylalanine mutations in the predicted transmembrane domain of P-glycoprotein. Phenylalanine ATP binding cassette subfamily B member 1 Homo sapiens
2 Site-directed mutagenesis was used to investigate whether phenylalanine residues in predicted transmembrane sequences play essential roles in the function of human P-glycoprotein. Phenylalanine ATP binding cassette subfamily B member 1 Homo sapiens
3 These results suggest that Phe-335 and Phe-978 play important roles in the recognition and transport of specific substrates by P-glycoprotein. Phenylalanine ATP binding cassette subfamily B member 1 Homo sapiens
4 These results suggest that Phe-335 and Phe-978 play important roles in the recognition and transport of specific substrates by P-glycoprotein. Phenylalanine ATP binding cassette subfamily B member 1 Homo sapiens