Title : Metabolism of the antimammary cancer antiestrogenic agent tamoxifen. I. Cytochrome P-450-catalyzed N-demethylation and 4-hydroxylation.

Pub. Date : 1993 Jul-Aug

PMID : 8104124






1 Functional Relationships(s)
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1 Mab anti-CYP2C11/2C6 (P-450h/k) inhibited N-demethylation in PB, PCN, and control male rat liver microsomes, suggesting that CYP2C11 and/or CYP2C6 catalyze this reaction to some extent. Phenobarbital cytochrome P450, subfamily 2, polypeptide 11 Rattus norvegicus