Title : Striatal Fos expression is indicative of dopamine D1/D2 synergism and receptor supersensitivity.

Pub. Date : 1993 Aug 15

PMID : 8102797






1 Functional Relationships(s)
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1 Separate administration of a high dose of a selective D1 (SKF 38393; 20 mg/kg) or D2 (quinpirole; 3 mg/kg) agonist induced Fos-like immunoreactivity in few neurons, whereas combined administration of the D1 and D2 agonists produced patches of intensely stained immunoreactive nuclei in the caudate-putamen. Quinpirole Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus