Title : Identification of major metabolites of the catechol-O-methyltransferase inhibitor nitecapone in the rat and dog.

Pub. Date : 1993 Mar-Apr

PMID : 8097704






1 Functional Relationships(s)
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1 Metabolites of nitecapone [3-(3,4-dihydroxy-5-nitrobenzylidene)-2,4-pentanedione], a potent catechol-O-methyltransferase inhibitor with gastroprotective and antiulcerogenic effects, were isolated by extraction and HPLC from dog and rat urine after enzymatic hydrolysis and as glucuronic acid and sulfate conjugates. nitecapone catechol-O-methyltransferase Canis lupus familiaris