Pub. Date : 1993 Feb
PMID : 8093872
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We have examined the release of gastrin and somatostatin from the isolated perfused stomach of rats of three different age groups (4 months, 12 months, and 24 months old) in response to bombesin and carbachol. | Carbachol | somatostatin | Rattus norvegicus |
| 2 | Carbachol inhibited release of somatostatin in each age group. | Carbachol | somatostatin | Rattus norvegicus |
| 3 | Compared with 4-month-old rats, the inhibition of somatostatin release by carbachol was less in 24-month-old rats at 10(-8) and 10(-7) M, and less in 12-month-old rats at 10(-7) M. The decreased basal gastrin secretion and well-preserved gastrin response were further confirmed in conscious aged rats tested by means of oral gavage with 10% peptone. | Carbachol | somatostatin | Rattus norvegicus |