Pub. Date : 1994 Sep
PMID : 8092321
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In the present study we hypothesized that N-acetyl-L-cysteine (NAC), by increasing the availability of reduced sulfhydryl groups, would enhance the antihypertensive response to the ACEIs captopril and enalaprilat by a mechanism dependent on nitric oxide. | Enalaprilat | X-linked Kx blood group | Homo sapiens |
| 2 | However, when the SHRs were pretreated with NAC, the same dose of enalaprilat significantly reduced blood pressure from 176 +/- 5 to 151 +/- 5 mmHg (n = 6). | Enalaprilat | X-linked Kx blood group | Homo sapiens |
| 3 | The results of this study suggest that NAC, a donor of sulfhydryl groups, potentiates the antihypertensive response to captopril and enalaprilat in SHR by a nitric oxide-dependent mechanism. | Enalaprilat | X-linked Kx blood group | Homo sapiens |