Title : Oxazaphosphorine-specific resistance in human MCF-7 breast carcinoma cell lines expressing transfected rat class 3 aldehyde dehydrogenase.

Pub. Date : 1994 Sep 16

PMID : 8083225






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The resistance conferred by ALDH to mafosfamide is OAP-specific since the 3A1-31A line is also resistant to 4-hydroperoxycyclophosphamide (2.9-fold) and 4-hydroperoxyifosfamide (3.2-fold) but not to the non-oxazaphosphorine drugs phosphoramide mustard and melphalan, which cannot be detoxified by aldehyde dehydrogenase enzymes. Melphalan aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus