Title : Effect of oxytocin on free intracellular Ca2+ levels and progesterone release by human granulosa-lutein cells.

Pub. Date : 1993 Nov

PMID : 8077313






4 Functional Relationships(s)
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1 Effect of oxytocin on free intracellular Ca2+ levels and progesterone release by human granulosa-lutein cells. Progesterone oxytocin/neurophysin I prepropeptide Homo sapiens
2 In the present study we used fura-2 microfluorimetry to investigate whether activation of the oxytocin receptor of cultured human granulosa-lutein cells causes intracellular calcium (Ca2+) signals and affects progesterone release. Progesterone oxytocin/neurophysin I prepropeptide Homo sapiens
3 Moreover, oxytocin release induced by hCG and a stimulatory effect of oxytocin on the hCG-induced progesterone production during the period of maximal responsiveness of cultured cells were found. Progesterone oxytocin/neurophysin I prepropeptide Homo sapiens
4 We, therefore, propose that oxytocin may have autocrine and/or paracrine functions in human granulosa-lutein cells, including fine-tuning of progesterone release. Progesterone oxytocin/neurophysin I prepropeptide Homo sapiens