Title : Role for autocrine TGF-beta 1 in regulating differentiation of a human leukemic cell line toward osteoclast-like cells.

Pub. Date : 1994 Sep

PMID : 8077286






8 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 TPA treatment, which induces partial differentiation of these cells, markedly increased TGF-beta 1 mRNA expression and growth factor release. Tetradecanoylphorbol Acetate transforming growth factor beta 1 Homo sapiens
2 The majority of TGF-beta 1 secreted by TPA-treated cells was in its latent form. Tetradecanoylphorbol Acetate transforming growth factor beta 1 Homo sapiens
3 However, anti-TGF-beta antibodies inhibited TGF-beta 1 and TPA-induced growth inhibition, calcitonin responsiveness, and TRAcP activity, suggesting that the TPA effect is mediated in part by autocrine TGF-beta 1 and indicating that the cells can activate and respond to the TGF-beta that they secrete. Tetradecanoylphorbol Acetate transforming growth factor beta 1 Homo sapiens
4 However, anti-TGF-beta antibodies inhibited TGF-beta 1 and TPA-induced growth inhibition, calcitonin responsiveness, and TRAcP activity, suggesting that the TPA effect is mediated in part by autocrine TGF-beta 1 and indicating that the cells can activate and respond to the TGF-beta that they secrete. Tetradecanoylphorbol Acetate transforming growth factor beta 1 Homo sapiens
5 However, anti-TGF-beta antibodies inhibited TGF-beta 1 and TPA-induced growth inhibition, calcitonin responsiveness, and TRAcP activity, suggesting that the TPA effect is mediated in part by autocrine TGF-beta 1 and indicating that the cells can activate and respond to the TGF-beta that they secrete. Tetradecanoylphorbol Acetate transforming growth factor beta 1 Homo sapiens
6 However, anti-TGF-beta antibodies inhibited TGF-beta 1 and TPA-induced growth inhibition, calcitonin responsiveness, and TRAcP activity, suggesting that the TPA effect is mediated in part by autocrine TGF-beta 1 and indicating that the cells can activate and respond to the TGF-beta that they secrete. Tetradecanoylphorbol Acetate transforming growth factor beta 1 Homo sapiens
7 However, anti-TGF-beta antibodies inhibited TGF-beta 1 and TPA-induced growth inhibition, calcitonin responsiveness, and TRAcP activity, suggesting that the TPA effect is mediated in part by autocrine TGF-beta 1 and indicating that the cells can activate and respond to the TGF-beta that they secrete. Tetradecanoylphorbol Acetate transforming growth factor beta 1 Homo sapiens
8 However, anti-TGF-beta antibodies inhibited TGF-beta 1 and TPA-induced growth inhibition, calcitonin responsiveness, and TRAcP activity, suggesting that the TPA effect is mediated in part by autocrine TGF-beta 1 and indicating that the cells can activate and respond to the TGF-beta that they secrete. Tetradecanoylphorbol Acetate transforming growth factor beta 1 Homo sapiens