Title : Inhibition of DNA topoisomerases I and II and induction of apoptosis by erbstatin and tyrphostin derivatives.

Pub. Date : 1994 Aug 3

PMID : 8068042






1 Functional Relationships(s)
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1 Eleven erbstatin and tyrphostin derivatives, which inhibit epidermal growth factor receptor PTK activity by competing with both the peptide substrate and ATP were tested for their capacity to inhibit DNA topoisomerases I and II. Tyrphostins protein tyrosine kinase 2 beta Homo sapiens