Pub. Date : 1994 Sep 1
PMID : 8064238
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Allele specificity of structural requirement for peptides bound to HLA-DRB1*0405 and -DRB1*0406 complexes: implication for the HLA-associated susceptibility to methimazole-induced insulin autoimmune syndrome. | Methimazole | major histocompatibility complex, class II, DR beta 1 | Homo sapiens |
| 2 | Allele specificity of structural requirement for peptides bound to HLA-DRB1*0405 and -DRB1*0406 complexes: implication for the HLA-associated susceptibility to methimazole-induced insulin autoimmune syndrome. | Methimazole | major histocompatibility complex, class II, DR beta 1 | Homo sapiens |
| 3 | Allele specificity of structural requirement for peptides bound to HLA-DRB1*0405 and -DRB1*0406 complexes: implication for the HLA-associated susceptibility to methimazole-induced insulin autoimmune syndrome. | Methimazole | major histocompatibility complex, class II, DR beta 1 | Homo sapiens |
| 4 | It is noteworthy that all patients with methimazole-induced insulin autoimmune syndrome are positive for DRB1*0406 and negative for DRB1*0405. | Methimazole | major histocompatibility complex, class II, DR beta 1 | Homo sapiens |
| 5 | It is noteworthy that all patients with methimazole-induced insulin autoimmune syndrome are positive for DRB1*0406 and negative for DRB1*0405. | Methimazole | major histocompatibility complex, class II, DR beta 1 | Homo sapiens |
| 6 | Although this fragment probably exists at a very low level under normal physiological conditions due to the disulfide bond between flanking cysteine residues (6Cys-11Cys), a reducing compound such as methimazole may cleave the disulfide bond in vivo and allow DR alpha-DRB1*0406 complex on antigen-presenting cells to bind much of the linear fragment of insulin alpha chain, which may lead to the activation of self-insulin-specific T-helper cells. | Methimazole | major histocompatibility complex, class II, DR beta 1 | Homo sapiens |