Title : pH-independent and -dependent cleavage of proinsulin in the same secretory vesicle.

Pub. Date : 1994 Sep

PMID : 8063854






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1 By quantitative immunoelectron microscopy and HPLC, we have studied the effect of disrupting pH gradients, by ammonium chloride, on proinsulin conversion in the insulin-producing B-cells of the islets of langerhans. Ammonium Chloride insulin Homo sapiens