Pub. Date : 1994 Jun
PMID : 8062861
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Bradykinin and thrombin stimulate release of arachidonic acid and formation of prostanoids in human periodontal ligament cells. | Prostaglandins | coagulation factor II, thrombin | Homo sapiens |
| 2 | In the present study, the effect of bradykinin (BK) and thrombin, two inflammatory mediators, on prostanoid biosynthesis in human PDL-cells was investigated. | Prostaglandins | coagulation factor II, thrombin | Homo sapiens |
| 3 | BK and BK-B2 receptor agonists as well as thrombin, but not BK-B1 receptor agonists, also significantly increased [3H] release in human PDL-cells prelabelled with [3H]-arachidonic acid, indicating that BK and thrombin stimulate prostanoid biosynthesis, at least partly, due to activation of phospholipase A2. | Prostaglandins | coagulation factor II, thrombin | Homo sapiens |
| 4 | These data show that BK via BK-B2 receptors, as well as thrombin, have the capacity to stimulate arachidonic acid release and subsequent prostanoid biosynthesis in human PDL-cells and thus may be implicated in the tissue reactions involved in orthodontic tooth movement. | Prostaglandins | coagulation factor II, thrombin | Homo sapiens |