Title : Phosphorylation of the guanine nucleotide exchange factor and eukaryotic initiation factor 2 by casein kinase II regulates guanine nucleotide binding and GDP/GTP exchange.

Pub. Date : 1994 Aug 9

PMID : 8049218






2 Functional Relationships(s)
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1 Phosphorylation of the 82-kDa subunit of GEF in vitro by casein kinase (CK) II results in the stimulation of guanine nucleotide exchange [Dholakia, J. N., & Wahba, A. J. Guanine Nucleotides Rho/Rac guanine nucleotide exchange factor 2 Homo sapiens
2 In this study we demonstrate that treatment of CK-II-phosphorylated GEF or eIF-2 with alkaline phosphatase specifically removes more than 85% of the phosphate incorporated into the factors and alters guanine nucleotide binding to these proteins. Guanine Nucleotides Rho/Rac guanine nucleotide exchange factor 2 Homo sapiens