Title : Scrapie-associated PrP accumulation and its inhibition: revisiting the amyloid-glycosaminoglycan connection.

Pub. Date : 1994 Jun 6

PMID : 8030949






1 Functional Relationships(s)
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1 Using scrapie-infected neuroblastoma cells to screen for such compounds in vitro, we found that the amyloid binding dye Congo red and certain sulfated glycans potently inhibited the accumulation of protease-resistant PrP in scrapie-infected cells without apparent effects on the metabolism of the normal isoform. Congo Red prion protein Homo sapiens