Title : Regulation of rat brain natriuretic peptide transcription. A potential role for GATA-related transcription factors in myocardial cell gene expression.

Pub. Date : 1994 Jul 8

PMID : 8027030






7 Functional Relationships(s)
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1 Upon isolating and sequencing 2.5 kilobases of the rat BNP 5"-flanking sequence (FS), a variety of putative transcriptional enhancer sites were identified, including several GATA consensus sequences (WGATAR), one of which apparently serves as the major promoter site. gata natriuretic peptide B Rattus norvegicus
2 Truncation analyses showed that inducibility mapped primarily to the proximal -116 base pair of the rat BNP 5"-FS, where there are two consensus GATA sites in addition to the GATA sequence at the TATA box. gata natriuretic peptide B Rattus norvegicus
3 Truncation analyses showed that inducibility mapped primarily to the proximal -116 base pair of the rat BNP 5"-FS, where there are two consensus GATA sites in addition to the GATA sequence at the TATA box. gata natriuretic peptide B Rattus norvegicus
4 These results demonstrate that a proximal region of the rat BNP 5"-FS is required for growth factor- and GATA-inducible transcription, supporting the view that the BNP gene could serve as a target for GATA-binding proteins during early cardiac development. gata natriuretic peptide B Rattus norvegicus
5 These results demonstrate that a proximal region of the rat BNP 5"-FS is required for growth factor- and GATA-inducible transcription, supporting the view that the BNP gene could serve as a target for GATA-binding proteins during early cardiac development. gata natriuretic peptide B Rattus norvegicus
6 These results demonstrate that a proximal region of the rat BNP 5"-FS is required for growth factor- and GATA-inducible transcription, supporting the view that the BNP gene could serve as a target for GATA-binding proteins during early cardiac development. gata natriuretic peptide B Rattus norvegicus
7 These results demonstrate that a proximal region of the rat BNP 5"-FS is required for growth factor- and GATA-inducible transcription, supporting the view that the BNP gene could serve as a target for GATA-binding proteins during early cardiac development. gata natriuretic peptide B Rattus norvegicus