Pub. Date : 1994
PMID : 8020872
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The structure activity relationship of phosphoramidon analogues was studied for their ability to reduce the hypertensive effect of exogenous proET-1, probably via inhibition of an endothelin converting enzyme activity (ECE). | phosphoramidon | endothelin converting enzyme 1 | Homo sapiens |
| 2 | Furthermore, the tryptophan residue of phosphoramidon appeared to be particularly important for the ECE inhibition, whereas thermolysin inhibition seemed to depend greatly on the leucine residue. | phosphoramidon | endothelin converting enzyme 1 | Homo sapiens |
| 3 | It is concluded that in vivo ECE and thermolysin differ in the way they recognise phosphoramidon. | phosphoramidon | endothelin converting enzyme 1 | Homo sapiens |
| 4 | The existence of an hydrophobic pocket, specific for the recognition of the tryptophan residue of phosphoramidon, could be proposed for ECE. | phosphoramidon | endothelin converting enzyme 1 | Homo sapiens |