Title : Blockade of nicotinic responses by physostigmine, tacrine and other cholinesterase inhibitors in rat striatum.

Pub. Date : 1994 Mar

PMID : 8019748






2 Functional Relationships(s)
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1 Physostigmine, neostigmine, tacrine and DFP (all at 30 microM) each produced near-total (> 96%) inhibition of AChE activity. Isoflurophate acetylcholinesterase Rattus norvegicus
2 However, DFP at a concentration (60 microM) that produced a degree of AChE inhibition equal to that of physostigmine 30 microM, did not significantly reduce nicotine-induced dopamine release. Isoflurophate acetylcholinesterase Rattus norvegicus