Title : Tumor-promoting phorbol ester transiently down-modulates the p53 level and blocks the cell cycle.

Pub. Date : 1994 Mar

PMID : 8018565






3 Functional Relationships(s)
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1 Activation of the protein kinase C signaling pathway by tumor-promoting phorbol esters, such as 4 beta-phorbol 12-myristate 13-acetate (PMA), induced a decrease in the level of p53 mRNA in several serum-starved human cell lines. Tetradecanoylphorbol Acetate tumor protein p53 Homo sapiens
2 Activation of the protein kinase C signaling pathway by tumor-promoting phorbol esters, such as 4 beta-phorbol 12-myristate 13-acetate (PMA), induced a decrease in the level of p53 mRNA in several serum-starved human cell lines. Tetradecanoylphorbol Acetate tumor protein p53 Homo sapiens
3 PMA induced a similar transient decrease in the level of p53 protein in the A549 cell line. Tetradecanoylphorbol Acetate tumor protein p53 Homo sapiens