Title : Bacteremia due to fluoroquinolone-resistant Escherichia coli in two immunocompromised patients.

Pub. Date : 1994 Feb

PMID : 8013490






2 Functional Relationships(s)
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1 In a supercoiling assay using the purified DNA gyrase and plasmid pBR322, high concentrations (> or = 250 micrograms/ml) of both ofloxacin and ciprofloxacin were needed for visible inhibition of enzyme activity suggesting mutations in the DNA gyrase gene as the significant mechanism of resistance in both strains. Ofloxacin DNA topoisomerase II alpha Homo sapiens
2 In a supercoiling assay using the purified DNA gyrase and plasmid pBR322, high concentrations (> or = 250 micrograms/ml) of both ofloxacin and ciprofloxacin were needed for visible inhibition of enzyme activity suggesting mutations in the DNA gyrase gene as the significant mechanism of resistance in both strains. Ofloxacin DNA topoisomerase II alpha Homo sapiens