Title : Steroid binding and metabolism in the luteinizing hormone-releasing hormone-producing neuronal cell line GT1-1.

Pub. Date : 1994 Dec

PMID : 7988451






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 LHRH synthesis and release are modulated in vivo by gonadal steroids. Steroids gonadotropin releasing hormone 1 Mus musculus
2 Although immunocytochemical and autoradiographic studies failed to detect appreciable amounts of estrogen or androgen receptor in LHRH-producing neurons, the recent finding that the promoter region of the LHRH gene contains several steroid hormone-responsive elements indicates a possible direct effect of sex steroids on these specialized neurons. Steroids gonadotropin releasing hormone 1 Mus musculus
3 Although immunocytochemical and autoradiographic studies failed to detect appreciable amounts of estrogen or androgen receptor in LHRH-producing neurons, the recent finding that the promoter region of the LHRH gene contains several steroid hormone-responsive elements indicates a possible direct effect of sex steroids on these specialized neurons. Steroids gonadotropin releasing hormone 1 Mus musculus
4 In conclusion, GT1-1 cells possess several elements of the machinery through which sex steroids may influence LHRH dynamics. Steroids gonadotropin releasing hormone 1 Mus musculus