Title : Phorbol ester-, but not ligand-mediated activation of protein kinase C increases angiotensin binding to rat intestinal epithelial (RIE-1) cells.

Pub. Date : 1994 Aug

PMID : 7987254






1 Functional Relationships(s)
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1 Whereas direct activation of protein kinase C (PKC) by the phorbol ester, 12-O-tetradecanoyl-phorbol-13-acetate (TPA) increased the subsequent binding of 125I-labelled angiotensin II (125I-AII; 0.5 nM) to RIE-1 cells, ligand-mediated activation of the kinase via angiotensin II (AII), which activates the phosphoinositide (PI) pathway in these cells, had no effect. Phorbol Esters angiotensinogen Rattus norvegicus