Title : The effects of natural and synthetic retinoids on the differentiation of RCJ C5.18 chondrogenic cells.

Pub. Date : 1994 Jul

PMID : 7974255






2 Functional Relationships(s)
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1 Retinoic acid (RA) is known to inhibit the chondrogenic differentiation of C 5.18 cells and this may parallel the teratogenic effects of retinoids in vivo; however, the question as to which of the 3 retinoic acid receptors (RAR alpha, beta, gamma) or the 3 retinoid X receptors (RXR alpha, beta, gamma) mediate this RA-induced inhibition remains unanswered. Tretinoin retinoid X receptor alpha Homo sapiens
2 9-cis RA, which binds to the 3 RARs with affinities similar to RA and also binds to the 3 RXRs, was less active (IC50 8 x 10(-9) M), suggesting that RXR binding interferes with the inhibitory effect of ligand-activated RARs. Tretinoin retinoid X receptor alpha Homo sapiens