Title : The COMT inhibitor tolcapone potentiates the anticataleptic effect of Madopar in MPP(+)-lesioned mice.

Pub. Date : 1994 Oct 15

PMID : 7957769






2 Functional Relationships(s)
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1 In conclusion, the inhibitory effect of tolcapone on the O-methylation of levodopa to 3-OMD by COMT is largely due to improved levodopa and dopamine availability in the brain, and to the reduced formation of 3-OMD. Levodopa catechol-O-methyltransferase Mus musculus
2 In conclusion, the inhibitory effect of tolcapone on the O-methylation of levodopa to 3-OMD by COMT is largely due to improved levodopa and dopamine availability in the brain, and to the reduced formation of 3-OMD. Levodopa catechol-O-methyltransferase Mus musculus